SINCE 20005
PUBLICATIONS
Serena M, Molnar C, Velázquez D, Reina J, Llamazares S, Heinen JP, Mora J, and Gonzalez C. (2024). Human EWS-FLI protein levels and neomorphic functions show a complex, function-specific dose-response relationship in Drosophila. Royal Society Open Biol. 14: 240043. https://doi.org/10.1098/rsob.240043.
Molnar C, Heinen JP, Reina J, Llamazares S, Palumbo E, Pollarolo G, and Gonzalez C (2024). TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth. EMBO Rep (2024) https://doi.org/10.1038/s44319-024-00154-1.
Goupil A., Heinen J.P., Salame R., Rossi F., Reina J., Pennetier C., Simon A., Skorski P., Louzao A., Bardin A., Basto R., and Gonzalez C. (2022). Illuminati, a form of gene expression plasticity in Drosophila neural stem cells. Development 149 (22): dev200808. https://doi.org/10.1242/dev.200808
Molnar C., Reina J., Herrero A., Heinen J.P., Méndiz V., Bonnal S., Irimia M, Sánchez-Jiménez M., Sánchez-Molina S., Mora J., and Gonzalez C (2022). Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis. PNAS Nexus, pgac222, https://doi.org/10.1093/pnasnexus/pgac222
Climent-Cantó P., Molnar C., Santabárbara-Ruiz P., Prieto C., Abri J.F.l, Serras F. , Gonzalez C. (2022). Oxidative Stress Is Associated with Overgrowth in Drosophila l(3)mbt Mutant Imaginal Discs. Cells 11(16):2542. doi: 10.3390/cells11162542.
Deng Q., Wang C., Tat Koe C., Heinen J.P., Sing Tan Y., Li S., Gonzalez C., Sung W.K., and Wang H. (2022). Tumour Suppressor Parafibromin/Hyrax Governs Cell Polarity and Centrosome Assembly in Neural Stem Cells. PLOS Biology. 12;20(10):e3001834. doi: 10.1371/journal.pbio.3001834.
Freier R., Aragon E., Bagiński B., Pluta R., Martin-Malpartida P., Ruiz L., Condeminas M., Gonzalez C., Macias M. (2021). Structures of the germline-specific Deadhead and Thioredoxin T proteins from Drosophila melanogaster reveal unique features among Thioredoxins. Intl. Union of Cristallography J. (IUCrJ) Volume 8 Part 2 March 2021. https://journals.iucr.org/m/issues/2021/02/00/jt5053/index.html. BioRxiv doi: https://doi.org/10.1101/2020.07.29.226944
REVIEW Gonzalez C. (2020). Centrosomes in asymmetric cell division. Current Opinion in Structural Biology. Volume 66, February 2021, Pages 178-182. https://doi.org/10.1016/j.sbi.2020.10.023
Molnar C., Louzao A., and Gonzalez C. (2020) Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein Tiny Tim 2 in Drosophila Somatic Epithelia. Cells 2020, 9, 1842; doi:10.3390/cells9081842
Molnar C, Heinen JP, Reina J, Llamazares S, Palumbo E, Breschi A, Gay M, Villarreal L, Vilaseca M, Pollarolo G and Gonzalez C. (2019) The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila. Science Advances Vol. 5, no. 8, eaaw7965. DOI: 10.1126/sciadv.aaw7965
Reina J, Gottardo M., Riparbelli, MG, Llamazares S, Callaini G, and Gonzalez C (2018). Centrobin is essential for C-tubule assembly and flagellum development in Drosophila melanogaster spermatogenesis. Journal of Cell Biology. DOI: 10.1083/jcb.201801032
Rossi F, Stephan-Otto Attolini C, Mosquera JL, Gonzalez C. (2018). Drosophila larval brain neoplasms present tumour-type dependent genome instability. G3: GENES, GENOMES, GENETICS April 1, 2018 vol. 8 no. 4 1205-1214; https://doi.org/10.1534/g3.117.300489. BioRxiv. doi: 10.1101/192492.
Rossi F, Molnar C, Hashiyama K, Heinen JP, Pampalona J, Llamazares S, Reina J, Hashiyama T, Rai M, Pollarolo G, Fernández-Hernández I, Gonzalez C. (2017) An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth. Open Biol. Aug;7(8). pii: 170156. doi: 10.1098/rsob.170156.
OPINION Fernández-Hernández I., Scheenaard E., Pollarolo G., Gonzalez C. (2016) The translational relevance of Drosophila in drug discovery.EMBO Reports. Apr;17(4):471-2.
Zhang Y., Rai M., Wang C., Gonzalez C., Wang H. (2016) Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Sci Rep. Mar 30;6:23735. doi: 10.1038/srep23735
Chen K., Koe C.T., Xing Z.B., Tian X., Rossi F., Wang C., Tang Q., Zong W., Hong W.J., Taneja R., Yu F., Gonzalez C., Wu C., Endow S., Wang H. (2016) Arl2- and Msps-dependent microtubule growth governs asymmetric division. J. Cell Biol. Mar 14;212(6): 661-76. doi: 10.1083/jcb.201503047.
COMMENT Gonzalez C. (2015) Cell division: A last-minute decision. Nature. N&V, 528:196-197. doi: 10.1038/528196a.
Rossi F. and Gonzalez C. (2015). Studying tumor growth in Drosophila using the tissue allograft method. Nature Protocols. 10:1525-1534. doi: 10.1038/nprot.2015.096.
Gottardo M, Pollarolo G, Llamazares S, Reina J, Riparbelli MG, Callaini G, Gonzalez C. (2015). Loss of Centrobin Enables Daughter Centrioles to Form Sensory Cilia in Drosophila. Current Biology 25:2319-2324. doi: 10.1016/j.cub.2015.07.038.
BOOK CHAPTER Pampalona, J., Januschke, J., Sampaio, P. & Gonzalez, C. (2015) Time-lapse recording of centrosomes and other organelles in Drosophila neuroblasts in Methods in cell biology. Centrosome & Centriole (Academic Press). vol 129 Chapter 16 pp301-316. Edited by Renata Basto & Karen Oegema.
COMMENT Pollarolo G., Gonzalez C. (2014) Quantitative differences, qualitative outcomes. Elife. Oct 29;3. doi: 10.7554/eLife.04869.
REVIEW Reina J., Gonzalez C. (2014) When fate follows age: unequal centrosomes in asymmetric cell division. Phil. Trans. R. Soc. B. doi:10.1098/rstb.2013.0466.
Koe CT, Li S, Rossi F, Wong JJ, Wang Y, Zhang Z, Chen K, Aw SS, Richardson HE, Robson P, Sung WK, Yu F, Gonzalez C, Wang H. (2014) The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages. Elife. doi: http://dx.doi.org/10.7554/eLife.01906.
BOOK CHAPTER Rebollo E, and Gonzalez C. (2013). Time-lapse imaging of embryonic neural stem cell division in Drosophila by two-photon microscopy. Current Protocols Select: Imaging and Microscopy, 561-570. Edited by S.C. Watkins & C.M. St Croix. J. Wiley & Sons, Inc. ISBN 978-1-118-04431-5 (pbk.)
Dos Santos H.G., Abia D., Janowski R., Mortuza G., Bertero M.G., Boutin M., Guarín N., Méndez-Giraldez R., Nuñez A., Pedrero J.G., Redondo P., Sanz M., Speroni S.,Teichert F., Bruix M., Carazo J.M., Gonzalez C., Reina J., Valpuesta J.M., Vernos I., Zabala J.C., Montoya G., Coll M., Bastolla U., Serrano L. (2013) Structure and non-structure of centrosomal proteins. PloS ONE. 8:5.
REVIEW Gonzalez, C. (2013) Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics. Nat Rev Cancer. Mar;13(3):172-83. doi: 10.1038/nrc3461.
Januschke, J., Reina, J., Llamazares, S., Bertran, T., Rossi, F., Roig, J., Gonzalez, C. (2013) Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts. Nat Cell Biol. Mar;15(3):241-8. doi: 10.1038/ncb2671.
REVIEW Mapelli, M., Gonzalez, C. (2012) On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN. Open Biol. 2:120102. http://dx.doi.org/10.1098/rsob.120102
Delgehyr, N., Wieland, U., Rangone, H., Pinson, X., Mao, G., Dzhindzhev, N.S., McLean, D., Riparbelli, M.G., Llamazares, S., Callaini, G., Gonzalez, C., Glover, D.M. (2012) Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability. Proc Natl Acad Sci U S A. 109:5729-34.
Haupt, A., Joberty, G., Bantscheff, M., Frohlich, H., Stehr, H., Schweiger, M.R., Fischer, A., Kerick, M., Boerno, ST., Dahl, A., Lappe, M., Lehrach, H., Gonzalez, C., Drewes, G., Lange, BM. (2012). Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics. BMC Cancer. 12:38.
Rossi, F., Gonzalez, C (2012). Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth. EMBO reports. 13:157-62. doi: 10.1038/embor.2011.230.
Wang, C., Song, Li, Januschke, J., Rossi F., Izumi Y., García-Alvárez, G., Gwee, Serene S.L., Soon, S.B., Sidhu, H.K., Yu, F. Matsuzaki, F., Gonzalez, C., Wang, H. (2011). An Ana2/Ctp/Mud complex regulates Apical/Basal Spindle Orientation in Drosophila neuroblasts. Developmental Cell. 21 3: 520-533.
Januschke, J., Llamazares, S., Reina, J., and Gonzalez, C. (2011). Drosophila neuroblasts retain the daughter centrosome. Nature Communications 2:243.
Janic, A., Mendizabal, L., Llamazares, S., Rossell, D. & Gonzalez, C. (2010). Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila. Science. 330:1824-1827.
BOOK CHAPTER. Rebollo E, and Gonzalez C. (2010). Time-lapse imaging of embryonic neural stem cell division in Drosophila by two-photon microscopy. Curr. Protoc. Stem Cell Biol. Chapter 1:Unit1H.2.
Chang, KC., Garcia-Alvarez, G., Somers, G., Sousa-Nunes, R., Rossi, F., Lee, Y. Y., Soon, SB, Gonzalez, C., Chia, W. & Wang, H. (2010). Interplay between the Transcription Factor Zif and aPKC Regulates Neuroblast Polarity and Self-Renewal. Developmental Cell. 19: 778-785.
REVIEW Lesage, B., Gutiérrez, I., Martí, E. & Gonzalez, C. (2010). Neural stem cells: the need for a proper orientation. Curr. Op. in Genetics & Development. 20:438-442.
Januschke, J., Gonzalez, C. (2010). The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. J. Cell Biol. 188:693-706.
REVIEW Tajbakhsh, S. & Gonzalez, C. (2009). Biased segregation of DNA and centrosomes- moving together or drifting apart? Nature Reviews Molecular Cell Biology. 10:804-810.
Rebollo E, Roldán M, Gonzalez C. (2009). Spindle alignment is achieved without rotation after the first cell cycle in Drosophila embryonic neuroblasts. Development. 136:3393-97.
Martinez AM , Schuettengruber B, Sakr S, Janic A, Gonzalez C, Cavalli G. (2009). Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nature Genetics. 41:1076-82.
OPINION ARTICLE Gonzalez C. (2008). Centrosome function during stem cell division: The devil is in the details. Curr. Op.Cell Biol. 20:694-8.
REVIEW Januschke J. & Gonzalez C. (2008). Drosophila asymmetric division, polarity and cancer. Oncogene. 27: 6994-7002.
Castellanos E., Dominguez P. & Gonzalez C. (2008) Centrosome dysfunction in Drosophila neural stem cells causes tumours that are not due to genome instability. Current Biology. 18:1209-14.
Dyer N, Rebollo E, Dominguez P, Elkhatib N, Chavrier P, Daviet L, Gonzalez C, and Gonzalez M. (2007). Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes. Development. 134: 4437-47.
Varmark, H., Llamazares, S., Rebollo, E., Lange, B., Reina, J., Schwarz, H., Gonzalez, C. (2007). Asterless is a centriolar protein required centrosome function and embryo development in Drosophila. Current Biology. 17: 1735-45.
REVIEW Gonzalez C. (2007) Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nature Reviews Genetics. 8: 462-472.
Rebollo E., Sampaio P.; Janushke J.; Llamazares S.; Varmark H. and Gonzalez C. (2007). Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. Developmental Cell. 12: 467-474.
Santori, M.I.; Gonzalez, C.; Serrano, L.; and M. Isalan (2006) Localized transfection on arrays of magnetic beads coated with PCR products. Nature Protocols. 1: 526-31.
REVIEW Wodarz, A., and Gonzalez, C. (2006). Connecting Cancer to the Asymmetric Division of Stem Cells. Cell. 124: 1121-1123.
Caussinus, E. and Gonzalez, C. (2005). Induction of tumor growth by altered stem-cell asymmetric division in Drosophila. Nature Genetics. 37:1125-1129.
Lange, B.M.., Kirfel, G., Gestmann, I., Herzog, V. and Gonzalez, C. (2005). Structure and microtubule-nucleation activity of isolated Drosophila embryo centrosomes characterized by whole mount scanning and transmission electron microscopy. Histochemistry and Cell Biology. 10:1-10.
Isalan, M., Santori, M.I., Gonzalez, C. and Serrano, L. (2005). Localised transfection on arrays of magnetic beads coated with PCR products. Nature Methods. 2:113-118.